Iridium-Catalyzed Asymmetric Ring-Opening Reactions of Oxabenzonorbornadienes with Amine Nucleophiles

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• 作者：Dingqiao Yang ; Yuhua Long ; Junfang Zhang ; Heping Zeng ; Sanyong Wang ; Chunrong Li
• 刊名：Organometallics
• 出版年：2010
• 出版时间：August 23, 2010
• 年：2010
• 卷：29
• 期：16
• 页码：3477-3480
• 全文大小：745K
• 年卷期：v.29,no.16(August 23, 2010)
• ISSN：1520-6041

文摘

We have explored a new iridium-catalyzed ring-opening reaction of oxabenzonorbornadienes with a variety of primary aromatic amine or N-substituted piperazine nucleophiles, affording the corresponding products in excellent yields (up to 99%) with moderate enantioselectivity (25−81% ee). The trans configuration of product 2d was confirmed by X-ray crystallography.