Unexpected Copper-Catalyzed Cascade Synthesis of Quinazoline Derivatives

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• 作者：Zhongyan Chen ; Jiuxi Chen ; Miaochang Liu ; Jinchang Ding ; Wenxia Gao ; Xiaobo Huang ; Huayue Wu
• 刊名：Journal of Organic Chemistry
• 出版年：2013
• 出版时间：November 15, 2013
• 年：2013
• 卷：78
• 期：22
• 页码：11342-11348
• 全文大小：418K
• 年卷期：v.78,no.22(November 15, 2013)
• ISSN：1520-6904

文摘

The first example of a copper-catalyzed cascade reaction of (2-aminophenyl)methanols with aldehydes using the combination of cerium nitrate hexahydrate and ammonium chloride has been developed, leading to a wide range of 2-substituted quinazolines in moderate to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of 2-substituted quinazoline derivatives.