Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones under Superheating Conditions by Using a Continuous Flow Microreactor System under Pressure

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• 作者：Lingjie Kong ; Xiaoming Lv ; Qi Lin ; Xiaofeng Liu ; Yaming Zhou ; Yu Jia
• 刊名：Organic Process Research & Development
• 出版年：2010
• 出版时间：July 16, 2010
• 年：2010
• 卷：14
• 期：4
• 页码：902-904
• 全文大小：190K
• 年卷期：v.14,no.4(July 16, 2010)
• ISSN：1520-586X

文摘

A simple and efficient method for the synthesis of 2,4,5-trisubstituted imidazoles has been developed by using a continuous flow microreactor system under pressure; aryl-, alkyl-, and heteroaryl-substituted imidazoles were obtained in high yields within 2 min under superheating conditions.