Sonication-Assisted Synthesis of Polyelectrolyte-Coated Curcumin Nanoparticles

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• 作者：Zhiguo Zheng ; Xingcai Zhang ; Daniel Carbo ; Cheryl Clark ; Cherie-Ann Nathan ; Yuri Lvov
• 刊名：Langmuir
• 出版年：2010
• 出版时间：June 1, 2010
• 年：2010
• 卷：26
• 期：11
• 页码：7679-7681
• 全文大小：673K
• 年卷期：v.26,no.11(June 1, 2010)
• ISSN：1520-5827

文摘

A new method of nanoparticle formulation for poorly water-soluble materials was demonstrated for curcumin. The drug was dissolved in organic solvent that is miscible with water (ethanol), and drug nucleation was initiated by gradual worsening of the solution by the addition of an aqueous polyelectrolyte assisted by ultrasonication. Curcumin crystals of 60−100 nm size were obtained depending on the component concentrations, sonication power, and initial solvent. Layer-by-layer shell assembly with biocompatible polyelectrolytes was used to provide a particle coating with a high surface potential and the stabilization of drug nanocolloids. Polyelectrolyte layer-by-layer encapsulation allowed sustained drug release from nanoparticles over the range of 10−20 h.