Copper-Catalyzed Multicomponent Reaction: Synthesis of 4-Arylsulfonylimino-4,5-dihydrofuran Derivatives

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• 作者：Yongjia Shang ; Kai Ju ; Xinwei He ; Jinsong Hu ; Shuyan Yu ; Min Zhang ; Kaisheng Liao ; Lifen Wang ; Ping Zhang
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：August 20, 2010
• 年：2010
• 卷：75
• 期：16
• 页码：5743-5745
• 全文大小：700K
• 年卷期：v.75,no.16(August 20, 2010)
• ISSN：1520-6904

文摘

A series of 4-arylsulfonylimino-4,5-dihydrofurans (14 examples) were efficiently synthesized in good to excellent yields by using the copper-catalyzed three-component reaction between sulfonyl azides, phenylacetylene, and β-ketoesters in tetrahydrofuran (THF) at 40 °C for 8 h in the presence of triethylamine (TEA). A plausible mechanism for this process is proposed.