Stereoselective Total Synthesis of (−)-Cleistenolide

详细信息    查看全文

• 作者：Chao Cai ; Jun Liu ; Yuguo Du ; Robert J. Linhardt
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：August 20, 2010
• 年：2010
• 卷：75
• 期：16
• 页码：5754-5756
• 全文大小：696K
• 年卷期：v.75,no.16(August 20, 2010)
• ISSN：1520-6904

文摘

A facile stereoselective total synthesis of cleistenolide (1) from the natural chiral template d-arabinose has been achieved in eight steps and 49% overall yield, employing key steps including Wittig olefination, selective 1,3-trans-acetal formation, and modified Yamaguchi esterification.