Efficient and Convenient Synthesis of Pyrrolo[1,2-a]quinazoline Derivatives with the Aid of Tin(II) Chloride

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• 作者：Manman Wang ; Guolan Dou ; Daqing Shi
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2010
• 出版时间：July 12, 2010
• 年：2010
• 卷：12
• 期：4
• 页码：582-586
• 全文大小：178K
• 年卷期：v.12,no.4(July 12, 2010)
• ISSN：1520-4774

文摘

An efficient, convenient, one-pot synthesis of 2,3,3a,4-tetrahydropyrrolo[1,2-a]quinazolin-5(1H)-one and 2,3,3a,4-tetrahydropyrrolo[1,2-a]quinazoline-1,5-dione was accomplished in good yields via the novel reductive cyclization of 2-nitrobenzamides with haloketones or keto acids mediated by SnCl₂·2H₂O system. A variety of substrates can participate in the process with good yields, making this methodology suitable for library synthesis in drug discovery efforts.