Neolignans and Glycosides from the Stem Bark of Illicium difengpi

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• 作者：Lei Fang ; Dan Du ; Guang-Zhi Ding ; Yi-Kang Si ; Shi-Shan Yu ; Yang Liu ; Wen-Jie Wang ; Shuang-Gang Ma ; Song Xu ; Jing Qu ; Jia-Ming Wang ; Yu-Xi Liu
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：May 28, 2010
• 年：2010
• 卷：73
• 期：5
• 页码：818-824
• 全文大小：205K
• 年卷期：v.73,no.5(May 28, 2010)
• ISSN：1520-6025

文摘

Five new neolignans (1−4 and 9), two pairs of neolignan epimers (5−8), and two new aromatic glycosides (10 and 11) have been isolated from the stem bark of Illicium difengpi. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRESIMS, CD experiments, and chemical methods. The absolute configurations of the 3,4-diol moiety in 1 and 1,3-diol moiety in 2 were confirmed by Snatzke’s method, observing the induced circular dichroism after addition of dimolybdenum tetraacetate in DMSO. Compounds 3, 4, and 11 exhibited moderate anti-inflammatory activities with IC₅₀ values ranging from 1.62 to 24.4 μM, while compound 3 displayed antioxidant activity with an IC₅₀ value of 42.3 μM.