Trichodermaketones A−D and 7-O-Methylkoninginin D from the Marine Fungus Trichoderma koningii

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• 作者：Fuhang Song ; Huanqin Dai ; Yaojun Tong ; Biao Ren ; Caixia Chen ; Nuo Sun ; Xiangyang Liu ; Jiang Bian ; Mei Liu ; Hong Gao ; Hongwei Liu ; Xiaoping Chen ; Lixin Zhang
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：May 28, 2010
• 年：2010
• 卷：73
• 期：5
• 页码：806-810
• 全文大小：125K
• 年卷期：v.73,no.5(May 28, 2010)
• ISSN：1520-6025

文摘

Five new polyketide derivatives, 7-O-methylkoninginin D (1) and trichodermaketones A−D (2−5), together with four known compounds, koninginins A, D, E, and F, were isolated from the marine-derived fungus Trichoderma koningii. Trichodermaketones A (2) and B (3) are unprecedented polyketides with a bistetrafuran-containing tricyclic skeleton. The chemical structures and absolute configurations of compounds 1−5 were elucidated by comparing with literature data and extensive spectroscopic methods, including 2D NMR and CD spectroscopic analysis. Compounds 1−5 were evaluated for action against bacteria and fungi and for synergistic antifungal activity. Compound 2 showed synergistic antifungal activity against Candida albicans with 0.05 μg/mL ketoconazole.