Recyclable Antibacterial Magnetic Nanoparticles Grafted with Quaternized Poly(2-(dimethylamino)ethyl methacrylate) Brushes

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• 作者：Hongchen Dong ; Jinyu Huang ; Richard R. Koepsel ; Penglin Ye ; Alan J. Russell ; Krzysztof Matyjaszewski
• 刊名：Biomacromolecules
• 出版年：2011
• 出版时间：April 11, 2011
• 年：2011
• 卷：12
• 期：4
• 页码：1305-1311
• 全文大小：873K
• 年卷期：v.12,no.4(April 11, 2011)
• ISSN：1526-4602

文摘

Highly efficient recyclable antibacterial magnetite nanoparticles consisting of a magnetic Fe₃O₄ core with an antibacterial poly(quaternary ammonium) (PQA) coating were prepared in an efficient four-step process. The synthetic pathway included: (1) preparation of Fe₃O₄ nanoparticles via coprecipitation of Fe²⁺/Fe³⁺ in the presence of an alkaline solution; (2) attachment of an ATRP initiating functionality to the surface of the nanoparticles; (3) surface-initiated atom transfer radical polymerization (ATRP) of 2-(dimethylamino)ethyl methacrylate (DMAEMA); and (4) transformation of PDMAEMA brushes to PQA via quaternization with ethyl bromide. The success of the surface functionalization was confirmed by FT-IR, thermal gravimetric analysis (TGA), elemental analysis, and transmission electron microscopy (TEM). The PQA-modified magnetite nanoparticles were dispersed in water and exhibited a response to an external magnetic field, making the nanoparticles easy to remove from water after antibacterial tests. The PQA-modified magnetite nanoparticles retained 100% biocidal efficiency against E. coli (10⁵ to 10⁶E. coli/mg nanoparticles) during eight exposure/collect/recycle procedures without washing with any solvents or water.