Assessing the Quantitative Relationships between Preschool Children鈥檚 Exposures to Bisphenol A by Route and Urinary Biomonitoring

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• 作者：Marsha K. Morgan ; Paul A. Jones ; Antonia M. Calafat ; Xiaoyun Ye ; Carry W. Croghan ; Jane C. Chuang ; Nancy K. Wilson ; Matthew S. Clifton ; Zaida Figueroa ; Linda S. Sheldon
• 刊名：Environmental Science & Technology
• 出版年：2011
• 出版时间：June 15, 2011
• 年：2011
• 卷：45
• 期：12
• 页码：5309-5316
• 全文大小：826K
• 年卷期：v.45,no.12(June 15, 2011)
• ISSN：1520-5851

文摘

Limited published information exists on young children鈥檚 exposures to bisphenol A (BPA) in the United States using urinary biomonitoring. In a previous project, we quantified the aggregate exposures of 257 preschool children to BPA in environmental and personal media over 48-h periods in 2000鈥?001 at homes and daycares in North Carolina and Ohio. In the present study for 81 Ohio preschool children ages 23鈥?4 months, we quantified the children鈥檚 urinary total BPA (free and conjugated) concentrations over these same 48-h periods in 2001. Then, we examined the quantitative relationships between the children鈥檚 intakes doses of BPA through the dietary ingestion, nondietary ingestion, and inhalation routes and their excreted amounts of urinary BPA. BPA was detected in 100% of the urine samples. The estimated median intake doses of BPA for these 81 children were 109 ng/kg/day (dietary ingestion), 0.06 ng/kg/day (nondietary ingestion), and 0.27 ng/kg/day (inhalation); their estimated median excreted amount of urinary BPA was 114 ng/kg/day. Our multivariable regression model showed that dietary intake of BPA (p = 0.04) and creatinine concentration (p = 0.004) were significant predictors of urinary BPA excretion, collectively explaining 17% of the variability in excretion. Dietary ingestion of BPA accounted for >95% of the children鈥檚 excreted amounts of urinary BPA.