Cysteine-Based Organocatalysts for the Highly Efficient Direct Stoichiometric anti- and syn-Aldol Reactions

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• 作者：Shi Li ; Chuanlong Wu ; Xiangkai Fu ; Qiang Miao
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2011
• 出版时间：December 21, 2011
• 年：2011
• 卷：50
• 期：24
• 页码：13711-13716
• 全文大小：854K
• 年卷期：v.50,no.24(December 21, 2011)
• ISSN：1520-5045

文摘

A series of cysteine-based organocatalysts have been designed and synthesized from a simple step. The anti-aldol and syn-aldol products could be obtained with up to 98:2 anti/syn and 99% ee; the stoichiometric ratio between aldehydes and ketones is 1. This catalyst could be easily recovered and efficiently used in large-scale reactions, which demonstrates its potential application in industry.