Chiral Allene-Containing Phosphines in Asymmetric Catalysis

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• 作者：Feng Cai ; Xiaotao Pu ; Xiangbing Qi ; Vincent Lynch ; Akella Radha ; Joseph M. Ready
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：November 16, 2011
• 年：2011
• 卷：133
• 期：45
• 页码：18066-18069
• 全文大小：820K
• 年卷期：v.133,no.45(November 16, 2011)
• ISSN：1520-5126

文摘

We demonstrate that allenes, chiral 1,2-dienes, appended with basic functionality can serve as ligands for transition metals. We describe an allene-containing bisphosphine that, when coordinated to Rh(I), promotes the asymmetric addition of arylboronic acids to 伪-keto esters with high enantioselectivity. Solution and solid-state structural analysis reveals that one olefin of the allene can coordinate to transition metals, generating bi- and tridentate ligands.