Steric and Electronic Effects in Capsule-Confined Green Fluorescent Protein Chromophores

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• 作者：Anthony Baldridge ; Shampa R. Samanta ; Nithyanandhan Jayaraj ; V. Ramamurthy ; Laren M. Tolbert
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：February 2, 2011
• 年：2011
• 卷：133
• 期：4
• 页码：712-715
• 全文大小：716K
• 年卷期：v.133,no.4(February 2, 2011)
• ISSN：1520-5126

文摘

The turn-on of emission in fluorescent protein chromophores sequestered in an 鈥渙ctaacid鈥?capsule is controlled by stereoelectronic effects described by a linear free energy relationship. The stereochemical effects are governed by both the positions and volumes of the aryl substituents, while the electronic effects, including ortho effects, can be treated with Hammett 蟽 parameters. The use of substituent volumes rather than A values reflects packing of the molecule within the confines of the capsule.