An Atom-Economic Synthesis of Nitrogen Heterocycles from Alkynes

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• 作者：Barry M. Trost ; Jean-Philip Lumb ; Joseph M. Azzarelli
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：February 2, 2011
• 年：2011
• 卷：133
• 期：4
• 页码：740-743
• 全文大小：779K
• 年卷期：v.133,no.4(February 2, 2011)
• ISSN：1520-5126

文摘

A robust route to 2,4-disubstituted pyrrole heterocycles relying upon a cascade reaction is reported. The reaction benefits from operational simplicity: it is air and moisture tolerant and is performed at ambient temperature. Control over the reaction conditions provides ready access to isopyrroles, 2,3,4-trisubstituted pyrroles, and 3-substituted pyrollidin-2-ones.