Lignans and Neolignans from Sinocalamus affinis and Their Absolute Configurations

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• 作者：Liang Xiong ; Chenggeng Zhu ; Yanru Li ; Ye Tian ; Sheng Lin ; Shaopeng Yuan ; Jinfeng Hu ; Qi Hou ; Naihong Chen ; Yongchun Yang ; Jiangong Shi
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1188-1200
• 全文大小：980K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Twenty-two new lignans and neolignans (1鈭?b>22), together with 14 known analogues, have been isolated from an ethanolic extract of the stem (with skin removed) of Sinocalamus affinis. Their structures were elucidated by spectroscopic and chemical methods. On the basis of systematic NMR and circular dichroism (CD) data analysis, the validity of J_7,8 and 螖未_C8鈭扖7 values to distinguish threo and erythro aryl glycerol units in different neolignans and the CD data [particularly the Rh₂(OCOCF₃)₄-induced CD data (the E band)] to determine the absolute configurations at C-8 (C-7) of the aryl glycerol units are discussed. At a concentration of 10 渭M, compounds 20 and 22 inhibited NO production in mouse peritoneal macrophages 84.2 卤 5.9% and 71.7 卤 1.0%, respectively. Compounds 19, 20, and 22 showed activity against serum deprivation induced PC12 cell damage by increasing the cell viability from 80.7 卤 2.8% to 91.6 卤 6.4%, 107.2 卤 8.0%, and 97.6 卤 8.5%, respectively.