Bioactive Neolignans and Lignans from the Bark of Machilus robusta

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• 作者：Yanru Li ; Wei Cheng ; Chenggen Zhu ; Chunsuo Yao ; Liang Xiong ; Ye Tian ; Sujuan Wang ; Sheng Lin ; Jinfeng Hu ; Yongchun Yang ; Ying Guo ; Ying Yang ; Yan Li ; Yuhe Yuan ; Naihong Chen ; Jiangong Shi
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：June 24, 2011
• 年：2011
• 卷：74
• 期：6
• 页码：1444-1452
• 全文大小：863K
• 年卷期：v.74,no.6(June 24, 2011)
• ISSN：1520-6025

文摘

Sixteen new neolignans and lignans (1鈥?b>16), together with 12 known analogues, have been isolated from an ethanol extract of the bark of Machilus robusta. Compounds 1 and 2 showed activity against HIV-1 replication in vitro, with IC₅₀ values of 2.52 and 2.01 渭M, respectively. At 10 渭M, 6, 8, and 9 reduced dl-galactosamine-induced hepatocyte (WB-F344 cells) damage, and 9 could additionally attenuate rotenone-induced PC12 cell damage. The known compounds (鈭?-pinoresinol (17) and (+)-lyoniresinol (18) were active against serum deprivation induced PC12 cell damage.