Cytotoxic C21 and C22 Terpenoid-Derived Metabolites from the Sponge Ircinia sp.

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• 作者：Jui-Hsin Su ; Shang-Wei Tseng ; Mei-Chin Lu ; Li-Lian Liu ; Yalan Chou ; Ping-Jyun Sung
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：September 23, 2011
• 年：2011
• 卷：74
• 期：9
• 页码：2005-2009
• 全文大小：750K
• 年卷期：v.74,no.9(September 23, 2011)
• ISSN：1520-6025

文摘

One novel C₂₁ terpenoidal natural product, ircinolin A (2), two new C₂₂ furanoterpene metabolites, 15-acetylirciformonin B (3) and 10-acetylirciformonin B (4), and two known compounds, irciformonin B (1) and irciformonin F (5), were isolated from the sponge Ircinia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data. Moreover, the absolute configuration of 1 was determined by Mosher鈥檚 method. Among these metabolites, 2 is the first C₂₁ terpenoid-derived metabolite to be reported from this genus. Compounds 1 and 3鈥?b>5 exhibited significant cytotoxic activity against K562, DLD-1, HepG2, and Hep3B cancer cell lines.