Selective Catalytic Hydrogenation of Nitro Groups in the Presence of Activated Heteroaryl Halides

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• 作者：Annie J. Kasparian ; Cecile Savarin ; Alan M. Allgeier ; Shawn D. Walker
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：December 2, 2011
• 年：2011
• 卷：76
• 期：23
• 页码：9841-9844
• 全文大小：233K
• 年卷期：v.76,no.23(December 2, 2011)
• ISSN：1520-6904

文摘

Chemoselective reduction of nitro groups in the presence of activated heteroaryl halides was achieved via catalytic hydrogenation with a commercially available sulfided platinum catalyst. The optimized conditions employ low temperature, pressure, and catalyst loading (<0.1 mol % Pt) to afford heteroaromatic amines with minimal hydrodehalogenation byproducts.