Antimalarial 尾-Carboline and Indolactam Alkaloids from Marinactinospora thermotolerans, a Deep Sea Isolate

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• 作者：Hongbo Huang ; Yueliang Yao ; Zhengxiang He ; Tingting Yang ; Junying Ma ; Xinpeng Tian ; Yayong Li ; Caiguo Huang ; Xiaoping Chen ; Wenjun Li ; Si Zhang ; Changsheng Zhang ; Jianhua Ju
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：October 28, 2011
• 年：2011
• 卷：74
• 期：10
• 页码：2122-2127
• 全文大小：281K
• 年卷期：v.74,no.10(October 28, 2011)
• ISSN：1520-6025

文摘

Four new 尾-carboline alkaloids, designated marinacarbolines A鈥揇 (1鈥?b>4), two new indolactam alkaloids, 13-N-demethyl-methylpendolmycin (5) and methylpendolmycin-14-O-伪-glucoside (6), and the three known compounds 1-acetyl-尾-carboline (7), methylpendolmycin (8), and pendolmycin (9) were obtained from the fermentation broth of Marinactinospora thermotolerans SCSIO 00652, a new actinomycete belonging to the family Nocardiopsaceae. Their structures were elucidated by extensive MS and 1D and 2D NMR spectroscopic data analyses. The structure of compound 1 was further confirmed by single-crystal X-ray crystallography. The new compounds 1鈥?b>6 were inactive against a panel of eight tumor cell lines (IC₅₀ > 50 渭M) but exhibited antiplasmodial activities against Plasmodium falciparum lines 3D7 and Dd2, with IC₅₀ values ranging from 1.92 to 36.03 渭M.