Cytotoxic Amide Alkaloids from Piper boehmeriaefolium

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• 作者：Gui-Hua Tang ; Dong-Mei Chen ; Bei-Ying Qiu ; Li Sheng ; Yue-Hu Wang ; Guang-Wan Hu ; Fu-Wei Zhao ; Li-Juan Ma ; Huan Wang ; Qiao-Qin Huang ; Jin-Jin Xu ; Chun-Lin Long ; Jia Li
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：January 28, 2011
• 年：2011
• 卷：74
• 期：1
• 页码：45-49
• 全文大小：154K
• 年卷期：v.74,no.1(January 28, 2011)
• ISSN：1520-6025

文摘

Eight new amide alkaloids (1鈭?b>8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC₅₀ value of 2.7 渭g/mL.