Synthesis and Self-Assembly of Thermoresponsive PEG-b-PNIPAM-b-PCL ABC Triblock Copolymer through the Combination of Atom Transfer Radical Polymerization, Ring-Opening Polymerization, an

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• 作者：Jiucun Chen ; Mingzhu Liu ; Honghong Gong ; Yinjuan Huang ; Chen Chen
• 刊名：Journal of Physical Chemistry B
• 出版年：2011
• 出版时间：December 22, 2011
• 年：2011
• 卷：115
• 期：50
• 页码：14947-14955
• 全文大小：922K
• 年卷期：v.115,no.50(December 22, 2011)
• ISSN：1520-5207

文摘

A well-defined thermoresponsive poly(ethylene glycol)-block-poly(N-isopropylacrylamide)-block-poly(蔚-caprolactone) (PEG₄₃-b-PNIPAM₈₂-b-PCL₈₇) triblock copolymer was synthesized by combination of atom transfer radical polymerization (ATRP), ring-opening polymerization (ROP), and click chemistry. The synthesis included the four steps, and all the structures of the polymers were determined. The thermoresponsive triblock copolymer can disperse in water at room temperature to form core鈥搒hell鈥揷orona micelles with the hydrophobic PCL block as core, the thermoresponsive PNIPAM block as shell, and the hydrophilic PEG block as corona. At temperatures above the lower critical solution temperature (LCST) of the PNIPAM block, the PNIPAM chains gradually collapse on the PCL core to shrink the size and change the structure of the resultant core鈥搒hell鈥揷orona micelles with temperature increasing.