Stimuli Response of Cystamine-Core Dendrimer Revealed by Diffusion and NOE NMR Studies

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• 作者：Xueyan Feng ; Yiyun Cheng ; Qinglin Wu ; Jiahai Zhang ; Tongwen Xu
• 刊名：Journal of Physical Chemistry B
• 出版年：2011
• 出版时间：April 14, 2011
• 年：2011
• 卷：115
• 期：14
• 页码：3777-3783
• 全文大小：1032K
• 年卷期：v.115,no.14(April 14, 2011)
• ISSN：1520-5207

文摘

Stimuli response behaviors of cystamine-core dendrimer in the presence of several reducing agents including vitamin C, sodium bisulfite, and dl-Dithiothreitol are described. A competitive redox cleavage and supramolecular aggregate formation model is proposed based on PFG NMR and ¹H NMR titration experiments. Furthermore, reduction-responsive release of guest molecules from interior pockets of the cystamine-core dendrimer is confirmed by NOE studies. The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes.