Facile Fabrication of Rare-Earth-Doped Gd2O3 Hollow Spheres with Upconversion Luminescence, Magnetic Resonance, and Drug Delivery Properties

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• 作者：Gan Tian ; Zhanjun Gu ; Xiaoxiao Liu ; Liangjun Zhou ; Wenyan Yin ; Liang Yan ; Shan Jin ; Wenlu Ren ; Gengmei Xing ; Shoujian Li ; Yuliang Zhao
• 刊名：Journal of Physical Chemistry C
• 出版年：2011
• 出版时间：December 8, 2011
• 年：2011
• 卷：115
• 期：48
• 页码：23790-23796
• 全文大小：928K
• 年卷期：v.115,no.48(December 8, 2011)
• ISSN：1932-7455

文摘

Rare-earth (RE)-doped gadolinium oxide (Gd₂O₃) hollow nanospheres have been successfully prepared on a large scale via a template-directed method using hydrothermal carbon spheres as sacrificed templates. Scanning electron microscope and transmission electron microscope images reveal that these hollow-structured nanospheres have the mesoporous shells that are composed of a large amount of uniform nanoparticles. By doping the RE ions (Yb/Er) into the Gd₂O₃ host matrix, these NPs emitted bright multicolored upconversion emissions that can be fine-tuned from green to red by adjusting the codoped Yb/Er ratio under 980 nm NIR laser excitation. The possibility of using these upconversion nanoparticles for optical imaging in vivo has been demonstrated. It was also shown that these Gd₂O₃ nanospheres brightened the T₁-weighted images and enhanced the r₁ relaxivity of water protons, which suggested that they could act as T₁ contrast agents for magnetic resonance (MR) imaging. Moreover, these hollow spheres can be used as drug delivery host carriers, and drug storage/release properties were investigated using ibuprofen as the model drug. As a result, the so-prepared nanoscaled Gd₂O₃ hollow spheres bearing upconversion luminescence, MR imaging, and drug delivery capabilities could be potentially employed for simultaneous MR/fluorescent imaging and therapeutic applications.