Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

详细信息    查看全文

• 作者：Stephen J. McMahon ; Wendy B. Hyland ; Emilie Brun ; Karl T. Butterworth ; Jonathan A. Coulter ; Thierry Douki ; David G. Hirst ; Suneil Jain ; Anthony P. Kavanagh ; Zeljka Krpetic ; Marcus H. Mendenhall ; Mark F. Muir ; Kevin M. Prise ; Herwig Requardt ; L茅on Sanche ; Giuseppe Schettino ; Fred J. Currell ; C茅cile Sicard-Roselli
• 刊名：Journal of Physical Chemistry C
• 出版年：2011
• 出版时间：October 20, 2011
• 年：2011
• 卷：115
• 期：41
• 页码：20160-20167
• 全文大小：860K
• 年卷期：v.115,no.41(October 20, 2011)
• ISSN：1932-7455

文摘

Gold nanoparticles (GNPs) are of considerable interest for use as a radiosensitizer, because of their biocompatibility and their ability to increase dose deposited because of their high mass energy absorption coefficient. Their sensitizing properties have been verified experimentally, but a discrepancy between the experimental results and theoretical predictions suggests that the sensitizing effect does not depend solely on gold鈥檚 superior absorption of energetic photons. This work presents the results of three sets of experiments that independently mapped out the energy dependence of the radiosensitizing effects of GNPs on plasmid DNA suspended in water. Incident photon energy was varied from 11.8 to 80 keV through the use of monochromatic synchrotron and broadband X-rays. These results depart significantly from the theoretical predictions in two ways: First, the sensitization is significantly larger than would be predicted; second, it does not vary with energy as would be predicted from energy absorption coefficients. These results clearly demonstrate that the effects of GNP-enhanced therapies cannot be predicted by considering additional dose alone and that a greater understanding of the processes involved is necessary for the development of future therapeutics.