Hollow Nanospheres Based on the Self-Assembly of Alginate-graft-poly(ethylene glycol) and 伪-Cyclodextrin

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• 作者：Xian-Wei Meng ; Wei Ha ; Cong Cheng ; Zhen-Qiang Dong ; Li-Sheng Ding ; Bang-Jing Li ; Sheng Zhang
• 刊名：Langmuir
• 出版年：2011
• 出版时间：December 6, 2011
• 年：2011
• 卷：27
• 期：23
• 页码：14401-14407
• 全文大小：866K
• 年卷期：v.27,no.23(December 6, 2011)
• ISSN：1520-5827

文摘

This article studies the self-assembly of alginate-graft-poly(ethylene glycol) (Alg-g-PEG) and 伪-cyclodextrin (伪-CD) in aqueous solution. It was found that they could form hollow spheres because of the formation of coil鈥搑od Alg-g-PEG/伪-CD inclusion complexes. In these Alg-g-PEG/伪-CD complexes, the 伪-CDs are stacked along the PEG side chains to form a rod block, and alginate main chains act as a coil block. More rod-like blocks in Alg-g-PEG/伪-CD favor the formation of small assemblies. The assemblies of Alg-g-PEG/伪-CD show a dependence on concentration, temperature, pH, and salt concentration. At low concentration (below 0.125%) or high temperature (above 32 掳C), Alg-g-PEG/伪-CD particles were unstable and disrupted. Increasing the salt or decreasing the pH resulted in the aggregation of Alg-g-mPEG/伪-CD particles, as detected by the increase in the recorded hydrodynamic diameter (D_h).