Regiospecific Synthesis of 1,2-Disubstituted (Hetero)aryl Fused Imidazoles with Tunable Fluorescent Emission

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• 作者：Dongbing Zhao ; Junyi Hu ; Ningjie Wu ; Xiaolei Huang ; Xurong Qin ; Jingbo Lan ; Jingsong You
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：December 16, 2011
• 年：2011
• 卷：13
• 期：24
• 页码：6516-6519
• 全文大小：794K
• 年卷期：v.13,no.24(December 16, 2011)
• ISSN：1523-7052

文摘

A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1,2-disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaffolds with tunable fluorescence emission. These fluorophores have been applied as fluorescent probes for live cell imaging.