Responsive Two-Photon Induced Europium Emission as Fluorescent Indicator for Paralytic Shellfish Saxitoxin

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• 作者：Shuzhong He ; Hongguang Li ; Yuk-Wang Yip ; Chi-Tung Yeung ; Yuen On Fung ; Hoi-Kuan Kong ; Ho-Lun Yeung ; Ga-Lai Law ; Ka-Leung Wong ; Chi-Sing Lee ; Michael Hon-Wah Lam ; Margaret B. Murphy ; Paul Kwan-Sing Lam ; Wing-Tak Wong
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：October 7, 2011
• 年：2011
• 卷：13
• 期：19
• 页码：5036-5039
• 全文大小：764K
• 年卷期：v.13,no.19(October 7, 2011)
• ISSN：1523-7052

文摘

A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (K_B = 6.1 脳 10⁴ M^鈥?) and triggers a two-photon induced f鈥揻 emission enhancement by over 100% and increases the two-photon absorption cross-section from 9 to 36 GM.