A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines

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• 作者：Kangjian Qiao ; Hui Zhou ; Wei Xu ; Wenjun Zhang ; Neil Garg ; Yi Tang
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：April 1, 2011
• 年：2011
• 卷：13
• 期：7
• 页码：1758-1761
• 全文大小：709K
• 年卷期：v.13,no.7(April 1, 2011)
• ISSN：1523-7052

文摘

A nonribosomal peptide synthetase-like enzyme (NRPS325) from Aspergillus terreus was reconstituted in vitro and was shown to synthesize thiopyrazines using an unprecedented mechanism. Substrate promiscuity of NRPS325 toward different amino acids and free thiols was explored to produce >60 different thiopyrazine compounds.