Palladium-Catalyzed Decarboxylative Coupling of Isatoic Anhydrides with Arylboronic Acids

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• 作者：Wei Lu ; Jiuxi Chen ; Miaochang Liu ; Jinchang Ding ; Wenxia Gao ; Huayue Wu
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：November 18, 2011
• 年：2011
• 卷：13
• 期：22
• 页码：6114-6117
• 全文大小：757K
• 年卷期：v.13,no.22(November 18, 2011)
• ISSN：1523-7052

文摘

The decarboxylative coupling of isatoic anhydrides with arylboronic acids was realized for the first time in the presence of Pd₂(dba)₃ and DPEphos, achieving aryl o-aminobenzoates with yields ranging from moderate to good. The efficiency of this procedure was demonstrated by good compatibility with fluoro, chloro, bromo, nitro, cyano, trifluoromethyl, formacyl, acetyl, thienyl, and naphthyl groups. Preliminary mechanistic experiments using deuterium labeling showed that the oxygen atom was derived from dioxygen.