Hygrocins C–G, Cytotoxic Naphthoquinone Ansamycins from gdmAI-Disrupted Streptomyces sp. LZ35

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• 作者：Chunhua Lu ; Yaoyao Li ; Jingjing Deng ; Shanren Li ; Yan Shen ; Haoxin Wang ; Yuemao Shen
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：December 27, 2013
• 年：2013
• 卷：76
• 期：12
• 页码：2175-2179
• 全文大小：260K
• ISSN：1520-6025

文摘

Six hygrocins, polyketides of ansamycin class, were isolated from the gdmAI-disrupted Streptomyces sp. LZ35. The planar structure of hygrocins C鈥揈 (1鈥?b>3) was determined by one-dimensional and two-dimensional NMR spectroscopy and high-resolution mass spectrometry. They are derivatives of hygrocin A but differ in the configuration at C-2 and the orientation of the C-3,4 double bond. Hygrocin F(4) and G(5) were shown to be isomers of hygrocin C (1) and B (6), respectively, due to the different alkyl oxygen participating in the macrolide ester linkage. Hygrocins C, D, and F were found to be toxic to human breast cancer MDA-MB-431 cells (IC₅₀ = 0.5, 3.0, and 3.3 渭M, respectively) and prostate cancer PC3 cells (IC₅₀ = 1.9, 5.0, and 4.5 渭M, respectively), while hygrocins B, E, and G were inactive.