Copper-Catalyzed Domino Addition/Double Cyclization: An Approach to Polycyclic Benzimidazole Derivatives

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• 作者：Guodong Yuan ; Haiquan Liu ; Jilong Gao ; Kangjian Yang ; Qingsheng Niu ; Hui Mao ; Xiaoxia Wang ; Xin Lv
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：February 21, 2014
• 年：2014
• 卷：79
• 期：4
• 页码：1749-1757
• 全文大小：535K
• ISSN：1520-6904

文摘

An efficient and versatile method for the assembly of novel polycyclic benzimidazole derivatives has been developed by Cu-catalyzed domino addition/double cyclization reactions. A wide variety of polycyclic benzimidazole derivatives, which might be used as synthetic medicines and functional materials, were successfully assembled from bis-(o-haloaryl)carbodiimides. Unexpected N-methylated benzo[4,5]imidazo[1,2-a]indoles can also be selectively assembled. Multibonds and polycyclic moieties were conveniently formed in one pot during these domino processes.