Chemical Constituents from Inonotus obliquus and Their Biological Activities

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• 作者：Chao Liu ; Cui Zhao ; Hong-Hui Pan ; Jie Kang ; Xiong-Tao Yu ; Hong-Qing Wang ; Bao-Ming Li ; Yi-Zhen Xie ; Ruo-Yun Chen
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：January 24, 2014
• 年：2014
• 卷：77
• 期：1
• 页码：35-41
• 全文大小：291K
• ISSN：1520-6025

文摘

Seven new triterpenes, inonotusol A鈥揋 (1鈥?b>7), one new diterpene, inonotusic acid (8), and 22 known compounds were isolated from Inonotus obliquus. Their structures were elucidated on the basis of spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (¹H鈥?sup>1H COSY, ROESY, HSQC, and HMBC) experiments. In in vitro assays, compounds 6 and 8鈥?b>16 showed hepatoprotective effects against d-galactosamine-induced WB-F344 cell damage, with inhibitory effects from 34.4% to 81.2%. Compounds 7, 17, and 18 exhibited selective cytotoxicities against KB, Bel-7402, or A-549 cell lines. Compounds 16 and 17 showed inhibitory effects against protein tyrosine kinases, with IC₅₀ values of 24.6 and 7.7 渭M, respectively.