FeCl3 Catalyzed Regioselective C-Alkylation of Indolylnitroalkenes with Amino Group Substituted Arenes

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• 作者：Manoj R. Zanwar ; Veerababurao Kavala ; Sachin D. Gawande ; Chun-Wei Kuo ; Wen-Chang Huang ; Ting-Shen Kuo ; Hsiu-Ni Huang ; Chiu-Hui He ; Ching-Fa Yao
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：February 21, 2014
• 年：2014
• 卷：79
• 期：4
• 页码：1842-1849
• 全文大小：399K
• ISSN：1520-6904

文摘

An efficient FeCl₃ catalyzed protocol for the synthesis of amino functionalized indolylnitroalkanes from easily available precursor indolylnitroalkenes and substituted amines has been developed. Regioselective C-alkylation in the presence of free amino substituted arenes occurred. The scope of this methodology shows good functional group tolerance, and further, this protocol was used to prepare indolylquinoline derivatives.