An Enzyme-Responsive Controlled Release System of Mesoporous Silica Coated with Konjac Oligosaccharide

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• 作者：Wei Guo ; Chunyu Yang ; Liru Cui ; Huiming Lin ; Fengyu Qu
• 刊名：Langmuir
• 出版年：2014
• 出版时间：January 14, 2014
• 年：2014
• 卷：30
• 期：1
• 页码：243-249
• 全文大小：414K
• ISSN：1520-5827

文摘

A simple and green method to fabricate an ingenious enzyme-responsive drug controlled release system was presented. Mesoporous silica material (mSiO₂) 100 nm in size was used as the host, and Konjac oligosaccharide (KOGC) was employed to seal the nanopores of mSiO₂ to inhibit the drug release. Rhodamine B was used as the model cargo to reveal the release behavior of the system. The KOGC-modified mSiO₂ (mSiO₂@KOGC) retains the drug until it reaches the colonic environment where bacteria secrete enzymes (尾-mannanase) can degrade KOGC and make drug release. The amount of KOGC and enzyme can be used to adjust the release performance. And all the release behaviors fit the two-step Higuchi model, which predominate by KOGC degradation and mesoporous structure, respectively. With well bioactivity and selectivity, the system has potential application as an oral medicine carrier for treating intestinal disease.