Dearomatization Strategy and Palladium-Catalyzed Domino Reaction: Construction of Azepino[5,4,3-cd]indoles from 2-Alkynylanilines

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• 作者：Chen Zheng ; Jin Jin Chen ; Renhua Fan
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：February 7, 2014
• 年：2014
• 卷：16
• 期：3
• 页码：816-819
• 全文大小：354K
• ISSN：1523-7052

文摘

A facile approach to construct 3,4-fused tricyclic azepino[5,4,3-cd]indoles from 2-alkynyl anilines, isocyanides, and 伪,尾-unsaturated acids is reported. This synthetic process involves a regioselective meta-functionalization of 2-alkynylanilines using a dearomatization strategy and a palladium(II)-catalyzed domino heterocyclization/Heck reaction.