Modification of Crystal Shape through Deep Temperature Cycling

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• 作者：Mo Jiang ; Xiaoxiang Zhu ; Mark C. Molaro ; Michael L. Rasche ; Haitao Zhang ; Keith Chadwick ; Davide M. Raimondo ; Kwang-Ki K. Kim ; Lifang Zhou ; Zhilong Zhu ; Min Hao Wong ; Des O鈥橤rady ; Dominique Hebrault ; John Tedesco ; Richard D. Braatz
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2014
• 出版时间：April 2, 2014
• 年：2014
• 卷：53
• 期：13
• 页码：5325-5336
• 全文大小：942K
• 年卷期：v.53,no.13(April 2, 2014)
• ISSN：1520-5045

文摘

The evolution of particle shape is an important consideration in many industrial crystallizations. This article describes the design of temperature-cycling experiments (between alternating positive and negative supersaturations) to substantially change crystal shape with only a small number of cycles. The growth and dissolution of monosodium glutamate crystals of varying shapes were monitored using in-process attenuated total reflection鈥揊ourier transform infrared spectroscopy (ATR-FTIR), focused beam reflectance measurement (FBRM), particle vision and measurement (PVM), and off-line optical microscopy. The growth and dissolution kinetics were estimated in a multidimensional population balance model based on solute concentration and crystal dimension measurements. This model fitted the experimental data with a limited number of parameters of small uncertainty. In addition, with the estimated kinetic parameters, the model predicted the crystal size and shape distribution in a different temperature-cycling experiment reasonably well. In contrast to previous studies that have estimated kinetics along multiple crystal axes in mixed-tank crystallizers, this study implements dissolution terms in the multidimensional population balance model along multiple axes.