DABCO-Catalyzed Synthesis of Trifluoromethylated Furans from Propargyl Alcohols and Methyl 2-Perfluoroalkynoate

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• 作者：Qinglei Chong ; Xiaoyi Xin ; Chunxiang Wang ; Fan Wu ; Haolong Wang ; Ji-cheng Shi ; Boshun Wan
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：March 7, 2014
• 年：2014
• 卷：79
• 期：5
• 页码：2105-2110
• 全文大小：346K
• 年卷期：v.79,no.5(March 7, 2014)
• ISSN：1520-6904

文摘

The DABCO-catalyzed reaction of propargyl alcohols with methyl 2-perfluoroalkynoate to give trifluoromethylated furans in up to 98% yield under mild conditions has been developed. The established allene鈥揺nol and control experiments indicate that the reaction should proceed through a Michael addition and Claisen rearrangement/cyclization process.