Limonoids from Aphanamixis polystachya and Their Antifeedant Activity

详细信息    查看全文

• 作者：Jie-Yun Cai ; Duo-Zhi Chen ; Shi-Hong Luo ; Ning-Chuan Kong ; Yu Zhang ; Ying-Tong Di ; Qiang Zhang ; Juan Hua ; Shu-Xi Jing ; Shun-Lin Li ; Sheng-Hong Li ; Xiao-Jiang Hao ; Hong-Ping He
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：March 28, 2014
• 年：2014
• 卷：77
• 期：3
• 页码：472-482
• 全文大小：478K
• 年卷期：v.77,no.3(March 28, 2014)
• ISSN：1520-6025

文摘

Eight new aphanamixoid-type aphanamixoids (C鈥揓, 1鈥?b>8) and six new prieurianin-type limonoids, aphanamixoids K鈥揚 (9鈥?b>14), along with 10 known terpenoids were isolated from Aphanamixis polystachya, and their structures were established by spectroscopic data analysis. Among the new limonoids, 13 compounds exhibited antifeedant activity against the generalist Helicoverpa armigera, a plant-feeding insect, at various concentration levels. In particular, compounds 1, 4, and 5 showed potent activities with EC₅₀ values of 0.017, 0.008, and 0.012 渭mol/cm², respectively. On the basis of a preliminary structure鈥揳ctivity relationship analysis, some potential active sites in the aphanamixoid-type limonoid molecules are proposed.