Temperature-Driven Switching of the Catalytic Activity of Artificial Glutathione Peroxidase by the Shape Transition between the Nanotubes and Vesicle-like Structures

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• 作者：Liang Wang ; Huixin Zou ; Zeyuan Dong ; Lipeng Zhou ; Jiaxi Li ; Quan Luo ; Junyan Zhu ; Jiayun Xu ; Junqiu Liu
• 刊名：Langmuir
• 出版年：2014
• 出版时间：April 15, 2014
• 年：2014
• 卷：30
• 期：14
• 页码：4013-4018
• 全文大小：309K
• 年卷期：v.30,no.14(April 15, 2014)
• ISSN：1520-5827

文摘

Smart supramolecular nanoenzymes with temperature-driven switching property have been successfully constructed by the self-assembly of supra-amphiphiles formed by the cyclodextrin-based host鈥揼uest chemistry. The self-assembled nanostructures were catalyst-functionalized and thermosensitively-functionalized through conveniently linking the catalytic center of glutathione peroxidase and thermosensitive polymer to the host cyclodextrin molecules.The ON鈥揙FF switches for the peroxidase activity by reversible transformation of nanostructures from tube to sphere have been achieved through changing the temperature. We anticipate that such intelligent enzyme mimics could be developed to use in an antioxidant medicine with controlled catalytic efficiency according to the needs of the human body in the future.