Dynamic Introduction of Cell Adhesive Factor via Reversible Multicovalent Phenylboronic Acid/cis-Diol Polymeric Complexes

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• 作者：Guoqing Pan ; Bingbing Guo ; Yue Ma ; Wenguo Cui ; Fan He ; Bin Li ; Huilin Yang ; Kenneth J. Shea
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：April 30, 2014
• 年：2014
• 卷：136
• 期：17
• 页码：6203-6206
• 全文大小：263K
• 年卷期：v.136,no.17(April 30, 2014)
• ISSN：1520-5126

文摘

In this work, dynamic introduction of bioactive RGD peptide on a matrix was successfully demonstrated via reversible multicovalent interactions within PBA/cis-diol polymeric complexes. These reversible, stable multiple interaction sites, in addition to a long accessible polymeric linker, enabled 鈥渞eversible鈥?control of cell adhesion by specific biomolecular exchange (e.g., glucose or fructose). This biomolecule-triggered, noninvasive strategy shows great promise for use in real-time biological research and mimics natural biomolecular feedback systems, thus having potential application in medical diagnoses and regenerative medicine.