Peniphenones A鈥揇 from the Mangrove Fungus Penicillium dipodomyicola HN4-3A as Inhibitors of Mycobacterium tuberculosis Phosphatase MptpB

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• 作者：Hanxiang Li ; Jieyi Jiang ; Zhaoming Liu ; Shaoe Lin ; Guoping Xia ; Xuekui Xia ; Bo Ding ; Lei He ; Yongjun Lu ; Zhigang She
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：April 25, 2014
• 年：2014
• 卷：77
• 期：4
• 页码：800-806
• 全文大小：374K
• 年卷期：v.77,no.4(April 25, 2014)
• ISSN：1520-6025

文摘

A pair of unusual benzannulated 6,6-spiroketal enantiomers [(鈭?-1 and (+)-1] and three new biogenetically related compounds (2鈥?b>4), together with two known related analogues (5 and 6), have been isolated from a mangrove fungus, Penicillium dipodomyicola HN4-3A. Their structures were elucidated on the basis of spectroscopic analysis (1D and 2D NMR data) and X-ray crystallography. The absolute configurations of enantiomers (鈭?-1 and (+)-1 were determined using quantum chemical calculations of the electronic circular dichroic (ECD) spectra. Compounds 2 and 3 exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with IC₅₀ values of 0.16 卤 0.02 and 1.37 卤 0.05 渭M, respectively.