Copper-Catalyzed Intramolecular Tandem Reaction of (2-Halogenphenyl)(3-phenyloxiran-2-yl)methanones: Synthesis of (Z)-Aurones

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• 作者：Yiyi Weng ; Qixu Chen ; Weike Su
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：May 2, 2014
• 年：2014
• 卷：79
• 期：9
• 页码：4218-4224
• 全文大小：286K
• 年卷期：v.79,no.9(May 2, 2014)
• ISSN：1520-6904

文摘

A convenient and efficient method for the copper-catalyzed synthesis of (Z)-aurones via intramolecular tandem reaction of (2-halogenphenyl)(3-phenyloxiran-2-yl)methanones is reported. Moreover, a plausible mechanism for the formation of (Z)-aurones is proposed. This is the first report on the synthesis of (Z)-aurones through copper-catalyzed Ullmann coupling reaction employing epoxides as substrates.