Functionalized Mesoporous Silica Nanoparticles with Mucoadhesive and Sustained Drug Release Properties for Potential Bladder Cancer Therapy

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• 作者：Quan Zhang ; Koon Gee Neoh ; Liqun Xu ; Shengjie Lu ; En Tang Kang ; Ratha Mahendran ; Edmund Chiong
• 刊名：Langmuir
• 出版年：2014
• 出版时间：June 3, 2014
• 年：2014
• 卷：30
• 期：21
• 页码：6151-6161
• 全文大小：682K
• 年卷期：v.30,no.21(June 3, 2014)
• ISSN：1520-5827

文摘

The synthesis of a series of 尾-cyclodextrin modified mesoporous silica nanoparticles with hydroxyl, amino, and thiol groups was described. A comparison of their mucoadhesive properties and potential as a drug delivery system for superficial bladder cancer therapy was made. The thiol-functionalized nanoparticles exhibit significantly higher mucoadhesivity on the urothelium as compared to the hydroxyl- and amino-functionalized nanoparticles. This is attributed to the formation of disulfide bonds between the thiol-functionalized nanoparticles and cysteine-rich subdomains of mucus glycoproteins. An anticancer drug, doxorubicin, was loaded into the mesopores of the thiol-functionalized nanoparticles, and sustained drug release triggered by acidic pH was achieved. The present study demonstrates that thiol-functionalized mesoporous silica nanoparticles are promising as a mucoadhesive and sustained drug delivery system for superficial bladder cancer therapy.