Synthesis and Self-Assembly of CO2鈥揟emperature Dual Stimuli-Responsive Triblock Copolymers

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• 作者：Bo-wen Liu ; Hang Zhou ; Si-tong Zhou ; Hui-juan Zhang ; An-Chao Feng ; Chun-mei Jian ; Jin Hu ; Wei-ping Gao ; Jin-ying Yuan
• 刊名：Macromolecules
• 出版年：2014
• 出版时间：May 13, 2014
• 年：2014
• 卷：47
• 期：9
• 页码：2938-2946
• 全文大小：555K
• 年卷期：v.47,no.9(May 13, 2014)
• ISSN：1520-5835

文摘

Poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) with a 尾-cyclodextrin (尾-CD) at the chain end was synthesized via atom transfer radical polymerization (ATRP); poly(蔚-caprolactone) (PCL) with a 鈭扖鈺怌鈥?segment and an adamantane (Ada) group at two ends, respectively, was prepared through ring-opening polymerization (ROP), and poly(N-isopropylacrylamide) (PNIPAM) with a 鈭扴鈥揅(S)鈥揝鈥?segment, which can be converted into a thiol group, was yielded by reversible addition鈥揻ragmentation chain transfer polymerization (RAFT). A supramolecular triblock stimuli-responsive copolymer PNIPAM-b-PCL-b-PDMAEMA having good biocompatibility with PNIPAM and PDMAEMA hydrophilic segments and PCL hydrophobic segment was constructed by thiol鈥揺ne Michael addition and host鈥揼uest interaction. The triblock copolymer could self-assemble into vesicles and respond to carbon dioxide (CO₂) gas and temperature reversibly. Under the stimulation of CO₂, the vesicular assemblies swelled obviously; while raising the temperature from 25 to 40 掳C, the assemblies displayed a conversion between vesicles and spherical micelles.