Self-Assembly of Hybridized Peptide Nucleic Acid Amphiphiles

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• 作者：Li-Han Liu ; Ze-Yong Li ; Lei Rong ; Si-Yong Qin ; Qi Lei ; Han Cheng ; Xiang Zhou ; Ren-Xi Zhuo ; Xian-Zheng Zhang
• 刊名：ACS Macro Letters
• 出版年：2014
• 出版时间：May 20, 2014
• 年：2014
• 卷：3
• 期：5
• 页码：467-471
• 全文大小：306K
• 年卷期：v.3,no.5(May 20, 2014)
• ISSN：2161-1653

文摘

In this report, a series of peptide nucleic acid amphiphiles (PNAAs) with hybridization properties were designed and synthesized. Driven by hydrophobic interaction, the hybridized PNAAs can form uniform micelles, the base stacking interaction from PNA segments further stabilized the micelles. The effects of hydrophobic alkyl chain length, structure of hydrophilic peptides, concentration, and pH on the self-assembly behavior of partly complementing PNAA duplexes were explored.