Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex

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• 作者：Mingjin Xie ; Weiping Liu ; Liguang Lou ; Xizhu Chen ; Qingsong Ye ; Yao Yu ; Qiaowen Chang ; Shuqian Hou
• 刊名：Inorganic Chemistry
• 出版年：2010
• 出版时间：July 5, 2010
• 年：2010
• 卷：49
• 期：13
• 页码：5792-5794
• 全文大小：654K
• 年卷期：v.49,no.13(July 5, 2010)
• ISSN：1520-510X

文摘

An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH₃)₂I₂] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent.