Interaction of Nanoparticles with Lipid Membrane

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• 作者：Yuri Roiter ; Maryna Ornatska ; Aravind R. Rammohan ; Jitendra Balakrishnan ; David R. Heine ; Sergiy Minko
• 刊名：Nano Letters
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：8
• 期：3
• 页码：941 - 944
• 全文大小：1095K
• 年卷期：v.8,no.3(March 2008)
• ISSN：1530-6992

文摘

A nanoscale range of surface feature curvatures where lipid membranes lose integrity and form pores has been found experimentally. The pores were experimentally observed in the L-α-dimyristoyl phosphatidylcholine membrane around 1.2−22 nm polar nanoparticles deposited on mica surface. Lipid bilayer envelops or closely follows surface features with the curvatures outside of that region. This finding provides essential information for the understanding of nanoparticle−lipid membrane interaction, cytotoxicity, preparation of biomolecular templates and supported lipid membranes on rough and patterned surfaces.