Dammarane-Type Triterpenoids from Gentianella azurea

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• 作者：Yu-jie Huang ; Hui Lu ; Xue-li Yu ; Shu-wei Zhang ; Wen-qiong Wang ; Lin-yin Fen ; Li-jiang Xuan
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：May 23, 2014
• 年：2014
• 卷：77
• 期：5
• 页码：1201-1209
• 全文大小：366K
• 年卷期：v.77,no.5(May 23, 2014)
• ISSN：1520-6025

文摘

Thirteen new dammarane-type triterpenoids (1鈥?b>13) and four known analogues, gentirigenic acid (14) and the gentirigeosides A, B, and E (15鈥?b>17), were isolated from Gentianella azurea. Their structures were elucidated by detailed analysis of the NMR, MS, and X-ray crystallographic data. This is the first report of dammarane-type triterpenoids in the Gentianella genus. In addition, the known structures of gentirigenic acid (14) and the gentirigeosides A, B, and E (15鈥?b>17) were revised based on the X-ray diffraction analysis. Gentirigeoside A (15) was found to inhibit nitric oxide production in RAW 264.7 macrophages with an IC₅₀ value of 6.6 卤 2.1 渭M.