Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development

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• 作者：Mark D. Wittman ; Joan M. Carboni ; Zheng Yang ; Francis Y. Lee ; Melissa Antman ; Ricardo Attar ; Praveen Balimane ; Chiehying Chang ; Cliff Chen ; Lorell Discenza ; David Frennesson ; Marco M. Gottardis ; Ann G
• 刊名：Journal of Medicinal Chemistry
• 出版年：2009
• 出版时间：December 10, 2009
• 年：2009
• 卷：52
• 期：23
• 页码：7360-7363
• 全文大小：744K
• 年卷期：v.52,no.23(December 10, 2009)
• ISSN：1520-4804

文摘

This report describes the biological activity, characterization, and SAR leading to 9d (BMS-754807) a small molecule IGF-1R kinase inhibitor in clinical development.